AGAP2 antibody
£227.50
AGAP2 antibody (FNab00205)
Product
| Cat # FNab00205 | Size 100ug |
Price
£227.50
|
Qty
|
Description
GTPase-activating protein(GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1(GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Specifications
| Manufacturer | FineTest |
|---|---|
| Manufacturer Cat# | FNab00205 |
| Product Size | 100ug |
| Antibody Type | Polyclonal |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Physical Appearance | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
| Alternate Names | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2)|Centaurin-gamma-1 (Cnt-g1)|GTP-binding and GTPase-activating protein 2 (GGAP2)|Phosphatidylinositol 3-kinase enhancer (PIKE)|AGAP2|CENTG1|KIAA0167 |
| Calculated MW | 125 kDa |
| Protein ID | Q99490 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, IHC, WB |
| Recommended dilution | WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Gene ID | 116986 |