ADAM17-Specific antibody
£210.00
ADAM17-Specific antibody (FNab00139)
Product
| Cat # FNab00139 | Size 100ug |
Price
£210.00
|
Qty
|
Description
The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
Specifications
| Manufacturer | FineTest |
|---|---|
| Manufacturer Cat# | FNab00139 |
| Product Size | 100ug |
| Antibody Type | Polyclonal |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Physical Appearance | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | ADAM metallopeptidase domain 17 |
| Alternate Names | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)|Snake venom-like protease|TNF-alpha convertase|TNF-alpha-converting enzyme|ADAM17|CSVP|TACE |
| Calculated MW | 29 kDa |
| Protein ID | P78536 |
| Reactivity | Human |
| Applications | ELISA, WB |
| Recommended dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Gene ID | 6868 |