Anti-8-oxoA DNA/RNA Damage [Clone 6E4] (12503-GRP)

This target is a byproduct of oxidative damage to the adenosine nucleobase in DNA, RNA, and nucleotides such as ATP. In DNA, 8-oxoA mispairs may reduce fidelity of replication and cause transcriptional errors by RNA pol II. In RNA, 8-oxoA damage leads to attenuation of mRNA translation. Specialized base excision repair machinery and nucleotide sanitation processes are present to reduce the mutagenic consequences of 8-oxoA. This antibody is the intellectual property of CymbaX, sequencing of this antibody is prohibited. Patent Pending