AD-8007 (E1930-GRP)

AD-8007 is a selective and brain-penetrant inhibitor of acetyl CoA synthase 2 (ACSS2). AD-8007 significantly reduces lipid storage, cell colony formation, acetyl-CoA levels and cell survival in vitro models, and increase tumor cell death, tumor burden and increases survival in in-vivo models. AD-8007 exhibits anti-cancer activity.