Trisialoganglioside GT1b, (bovine brain), (NH4+ salt)Trisialoganglioside GT1b, (bovine brain), (NH4+ salt)
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Trisialoganglioside GT1b, (bovine brain), (NH4+ salt)

GT1b

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GT1b induces degeneration of dopaminergic neurons and this may contribute to the initiation and/or progression of Parkinson’s disease.2 GT1b inhibits antigen or mitogen induced T-cell proliferative responses and has been identified as the botulinum toxin receptor, a rare toxin having severe physiological results.3 Borrelia burgdorferi (a gram negative bacteria) binds several glycosphingolipids including GT1b. GT1b is a scavenger for •OH radicals and protects against brain mtDNA damage, seizures, and lipid peroxidation induced by reactive oxygen species producers.4 Ehrlich tumor expresses the ganglioside GT1b, and anti-GT1b has great therapeutic potential against this cancer. This ganglioside has also been implicated in Miller Fisher syndrome.
Cat# Size Price Qty Buy
1063 5 mg £346.88

Additional Information

Property Value or Rating
Product Size 5 mg
Manufacturer Matreya, LLC
Empirical Formula C95H165N5O47•3NH3
CAS# 59247-13-1
Formula Weight 2129 +3NH3 (stearoyl)
Source natural
Purity 98+%
Analytical Methods TLC; identity confirmed by MS
Natural Source bovine
Solubility chloroform/methanol/DI water, 2:1:0.1; forms micellar solution in water
Physical Appearance solid
Storage -20°C
Dry Ice No
Hazardous No
References

1. Nicole Gaude, Journal of Biological Chemistry, Vol. 279:33 pp. 34624-34630, 2004 
2. John E. Froehlich, Christoph Benning, and Peter Do¨rmann, Journal of Biological Chemistry, Vol. 276:34 pp. 31806-31812, 2001 
3. Naoki Maeda, Lipids, Vol. 43 pp. 741-748, 2008

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