Phosphatidylinositol, (plant), (Na+ salt)/ml, 1 ml chloroformPhosphatidylinositol, (plant), (Na+ salt)/ml, 1 ml chloroform
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Phosphatidylinositol, (plant), (Na+ salt)/ml, 1 ml chloroform

PI (Na+salt)

The metabolism of inositol lipids is involved in the signal transduction of many hormones, neurotransmitters and growth factors.1,2,3 In the classical pathway, phosphatidylinositol-specific phospholipase C (PI-PLC) hydrolyzes phosphatidyl 4,5- bisphosphate (PIP2) to yield 1,2-diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). The role of IP3 and DAG as second messengers is well recognized. In a second, more recently discovered pathway, the activation of phosphoinositide 3- kinase results in the formation of three novel phosphatidyl (PI) lipids phosphorylated at the D3 positions of the inositol ring: PI-3-P, PI-3,4-P2, and PI-3,4,5-P3. These D3 lipids are not known substrates for any of the phospholipase C enzymes and function as second messengers. PI 3-kinase activity is correlated with many cellular processes including the regulation of cell growth, oncogenic transformation, chemotaxis and receptor down-regulation. A recent paper on the effect of PI-3,4-P2 on the Akt proto-oncogene product also contains protocols for applying PIP’s to cell cultures.4 Matreya’s synthetic phosphatidylinositols and inositol phosphates are excellent tools for investigating these second messengers, understanding the enzyme mechanisms involved in phosphoinositide metabolism and designing therapeutic pharmacological agents.
Cat# Size Price Qty Buy
1048 10 mg/ml, 1 ml chloroform £198.75

Additional Information

Property Value or Rating
Product Size 10 mg/ml, 1 ml chloroform
Manufacturer Matreya, LLC
Empirical Formula C45H78O13P•Na
CAS# 383907-36-6
Formula Weight 858 + Na (linoleoyl)
Solvent chloroform
Source natural
Purity 98+%
Analytical Methods TLC; identity confirmed by MS
Natural Source plant
Solubility chloroform, ethyl ether
Physical Appearance liquid
Storage -20°C
Dry Ice No
Hazardous Yes
References

1. Bruce A. Fenderson, E. M. Eddy, Sen-Itiroh Hakomori, BioEssays Vol. 12 pp. 173, 1990 
2. P.W. Majerus, Annual Review of Biochemistry Vol. 61 pp. 225-250, 1992 
3. Ao-Lin Hsu, et al., Journal of Biological Chemistry May, Vol. 275 pp. 16242-16250, 2000 
4. H. Shimamura, et al., Journal of American Society of Nephrology Vol. 14 pp. 1427-1434, 2003

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