N-Tetracosanoyl-D-erythro-sphingosineN-Tetracosanoyl-D-erythro-sphingosine
Move your mouse over image or click to enlarge

N-Tetracosanoyl-D-erythro-sphingosine

N-C24:0-D-erythro-Ceramide; N-Lignoceroyl-D-erythro-sphingosine

This product is a high purity ceramide that is ideal as a standard and for biological systems. It is a ceramide containing the long chain lignoceric acid and is common in some mammalian tissues such as the brain. Ceramide is a fatty acid amide of sphingosine. Ceramide functions as a precursor in the synthesis of sphingomyelin, glycosphingolipids, and of free sphingosine and fatty acids. The sphingosine can be phosphorylated to form sphingosine-1-phosphate. Two of ceramide’s metabolites, sphingosine-1-phosphate and glucosylceramide, produce cell proliferation and other cellular functions.1 Ceramide exerts numerous biological effects, including induction of cell maturation, cell cycle arrest, terminal cell differentiation, cell senescence, and cell death.2 Because of these effects ceramide has been investigated for its use in cancer treatment and many potential approaches to cancer therapy have been presented.3 Other effects include producing reactive oxygen in mitochondria (followed by apoptosis) and stimulating phosphorylation of certain proteins (especially mitogen activated protein). It also stimulates some protein phosphatases (especially protein phosphatase 2A) making it an important controller of protein activity.
Cat# Size Price Qty Buy
1916 5 mg £140.63

Additional Information

Property Value or Rating
Product Size 5 mg
Manufacturer Matreya, LLC
Empirical Formula C42H83NO3
CAS# 34435-05-7
Formula Weight 650.1
Solvent none
Source synthetic
Purity 98+%
Analytical Methods TLC, GC
Natural Source Synthetic
Solubility chloroform
Physical Appearance A neat solid
Storage -20°C
References

1. J. M. Hauser, B. M. Buehrer, and R. M. Bell “Role of ceramide in mitogenesis induced by exogenous sphingoid bases.” Journal of Biological Chemistry Vol. 269 pp. 6803, 1994 
2. N. S. Radin, “Killing tumours by ceramide-induced apoptosis: a critique of available drugs” Biochemical Journal, Vol. 371 pp. 243-256, 2003 
3. N. S. Radin, “Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria” Bioorganic and Medicinal Chemistry, Vol. 11(10) pp. 2123-2142, 2003

Related Documents