N-Hexadecanoyl-D9 (13,13,14,14,15,15,16,16,16)-ceramide trihexoside

N-Hexadecanoyl-D9 (13,13,14,14,15,15,16,16,16)-ceramide trihexoside

CTH-D9 ; Gb3-D9 ; Globotriaosylceramide-D9

This high purity deuterated product is ideal for the identification of ceramide trihexoside in samples and biological systems. Ceramide trihexoside (CTH) is a glycosphingolipid found mostly in mammalian cell membranes. It is involved in cellular signaling and has been identified as a receptor for various toxins including shiga toxins and shiga-like toxins.1 Some toxins, such as veratoxins from Escherichia coli, require specific fatty acids on the ceramide portion of CTH to show affinity in binding. An accumulation of CTH in the cellular membranes due to a lack of alpha-galactosidase to convert it into lactosyl ceramide results in Fabry disease.2 This product can be used as an excellent standard for the identification of CTH in Fabry disease by HPLC3 and mass spectrometry.4 An inability to convert CTH to globoside due to mutations in the gene sequence leads to the Pk blood group phenotype. It appears that under certain conditions CTH can enhance anticoagulant activity. CTH has also been studied as a tool to investigate lymphocyte activation.5
Cat# Size Price Qty Buy
1551 500 ug £620.50

Additional Information

Property Value or Rating
Product Size 500 ug
Manufacturer Matreya, LLC
Empirical Formula C52H88D9NO18
Formula Weight 1033
Source semisynthetic, porcine RBC
Analytical Methods TLC, identity confirmed by MS
Solubility Chloroform/methanol/DI water, 2:1:0.1
Physical Appearance solid
Storage -20°C

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