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Ceramide (EOS); EOS Ceramide 1

This product is a high purity omega-esterified ceramide that is ideal as a standard and for studies involving skin-barrier lipids. It is found almost exclusively in the epidermal layer, especially in the stratum corneum. The stratum corneum is the outermost cellular layer of the epidermis and functions as the permeability barrier in mammals. It contains 12 extractable ceramide fractions containing sphingosine, 6-hydroxysphingosine, dihydrosphingosine and phytosphingosine bases. The omega-esterified ceramides are formed from glucosylceramide and sphingomyelin in special lamellar bodies in epidermal cells from which they are excreted into the extracellular domain of the outermost cell layer of the epidermis. Mammalian skin contains significant amounts of sphingolipids (as much as 50% of the total lipids), particularly very long chain linoleoyl esterified ceramide and glucosylceramide (also called O-acylceramide and O-acylglucosylceramide). These lipids, which are mostly found in the extracellular domains, are vital to the water permeability barrier to prevent lethal loss of water and pathogen invasion. The omega-esterified ceramides can be covalently bound to proteins of the cornified envelope where they form a hydrophobic layer. A deficiency of linoleoyl omega-esterified ceramides is strongly correlated with skin diseases such as psoriasis and atopic dermatitis.
Cat# Size Price Qty Buy
2084 1 mg £402.05

Additional Information

Property Value or Rating
Product Size 1 mg
Manufacturer Matreya, LLC
Empirical Formula C66H125NO5
Formula Weight 1012.7
Solvent none
Source synthetic
Purity 98+%
Analytical Methods TLC, identity confirmed by MS
Natural Source Synthetic
Solubility chloroform, methanol, DMF
Physical Appearance A neat solid
Storage -20°C

1. B. Breiden and K. Sandhoff, The Role of Sphingolipid Metabolism in Coetaneous Permeability Barrier Formation. Biochimica et Biophysica Acta 1841 (2014) 441-452 
2. R. Sandhoff, Very long chain sphingolipids: Tissue expression, function and synthesis. FEBS Letters 584 (2010) 1907-1913 
3. Y. Masukawa et al., Characterization of overall ceramide species in human stratum corneum. Journal of Lipid Research 2008 vol. 49(7):1466-1476

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