Monosialoganglioside GM2, (NH4+ salt)Monosialoganglioside GM2, (NH4+ salt)
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Monosialoganglioside GM2, (NH4+ salt)

GM2

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 GM2 regulates the function of ciliary neurotrophic factor receptors. The accumulation of GM2 (due to a deficiency in beta-hexosaminidase) has characterized Tay-Sachs disease (due to a mutation in the gene HEXA) and Sandhoff disease (due to a mutation in the gene HEXB). A mutation in the GM2A gene results in GM2 activator deficiency that also leads to accumulation of GM2.4
Cat# Size Price Qty Buy
1502 500 ug £314.06

Additional Information

Property Value or Rating
Product Size 500 ug
Manufacturer Matreya, LLC
Empirical Formula C67H121N3O26 • NH3 (stearoyl)
CAS# 19600-01-2
Formula Weight 1384.7
Source natural
Purity 98+%
Analytical Methods TLC
Natural Source Human
Solubility chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
Physical Appearance A neat solid
Storage -20°C
References

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980 
2. T. Kolter, R. Proia, K. Sandhoff, J. Biol. Chem., Vol. 277, No. 29, pp. 25859-25862, 2002 
3. S. Birkle, G. Zeng, L. Gao, R.K. Yu, and J. Aubry, Biochimie, Vol. 85 pp. 455–463, 2003 
4. R. Gravel et al., The Metabolic and Molecular Bases of Inherited Disease (C. R. Scriver, W. S. Sly, B. Childs, A. L. Beaudet, D. Valle, K. W. Kinzler, and B. Vogelstein, eds) pp. 3827–3876, McGraw-Hill Inc., New York, 2001

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