Mixed Gangliosides, Purified (porcine), (NH4+ salt)Mixed Gangliosides, Purified (porcine), (NH4+ salt)
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Mixed Gangliosides, Purified (porcine), (NH4+ salt)

Mixed Gangliosides, purified, porcine (NH4+salt)

This product contains a natural mixture of gangliosides (approximately 98% GM1, GD1a, GD1b, and GT1b) found in the central nervous system of adult bovine. The ratio of different gangliosides changes according to age, species, and organ. Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. Gangliosides act as receptors for various toxins and bacteria, accumulate in different tumors, and aid in many neuronal functions. Therefore they are very important in therapeutic processes. Composition: Approximately 98% GM1, GD1a, GD1b, GT1b
Cat# Size Price Qty Buy
1525 25 mg £262.50

Additional Information

Property Value or Rating
Product Size 25 mg
Manufacturer Matreya, LLC
Formula Weight 0
Source natural
Purity 98+%
Analytical Methods TLC
Natural Source Animal/Porcine
Solubility chloroform/methanol/water 2:1:0.1, forms micellar solution in water
Physical Appearance A neat solid
Storage -20°C
References

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980 
2. T. Kolter, R. Proia, K. Sandhoff. Combinatorial Ganglioside Biosynthesis. J. Biol. Chem. July Vol. 277, No. 29, pp. 25859-25862, 2002 
3. S. Birkle, G. Zeng, L. Gao, R. K. Yu, and J. Aubry, Role of tumor-associated gangliosides in cancer progression. Biochimie, 85, 455–463, 2003

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