Methyl tetracosenoate (cis-15)Methyl tetracosenoate (cis-15)
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Methyl tetracosenoate (cis-15)

Methyl nervonate; C24:1 (cis-15)Methyl ester

This high purity omega-9 very long-chain fatty acid methyl ester is ideal as a standard and for biological studies. Nervonic acid is a fatty acid that is found in significant amounts in nerve tissue where it has many critical roles and by which it derives its name. Nervonic acid is very important in the biosynthesis of the nerve cell myelin and, together with lignoceric acid, it makes up 60% of the fatty acids acylated to the sphingomyelin of white matter. Amounts of nervonic acid acylated to sphingolipids, such as sphingomyelin, are highly decreased in demyelinating diseases such as adrenoleukodystrophy and multiple sclerosis1 and supplements rich in this fatty acid have been used to help treat these demyelination disorders. In chronic kidney disease nervonic acid has been demonstrated to be a marker for mortality.2 In addition to being prevalent in nerve cells nervonic acid is also present in significant quantities acylated to the sphingomyelin of red blood cells and can be used as an index of maturation of premature infants.3 The phospholipid fatty acid composition of children with attentiondeficit hyperactive disorder showed significantly lower concentrations of nervonic acid, along with other fatty acids, as compared with controls.4 Nervonic acid has been demonstrated to be an inhibitor of both DNA polymerase beta and of human immunodeficiency virus type-1 reverse transcriptase, although it is inhibited non-competitively.5 In addition to having vital roles in nerve cells nervonic acid is also an important component of plant lipids where it can be found in significant amounts in their oils.
Cat# Size Price Qty Buy
1156 100 mg £117.19

Additional Information

Property Value or Rating
Product Size 100 mg
Manufacturer Matreya, LLC
Empirical Formula C25H48O2
CAS# 2733-88-2
Formula Weight 381
Solvent none
Source synthetic
Purity 99%
Analytical Methods GC, TLC
Solubility chloroform, hexane, ethyl ether
Physical Appearance liquid
Storage -20°C
Dry Ice No
Hazardous No
References

1. J. Sargent, K. Coupland, and R. Wilson “Nervonic acid and demyelinating disease” Medical Hypotheses, vol. 42 pp. 237-242, 1994 
2. G. Shearer et al. “Plasma Fatty Acids in Chronic Kidney Disease: Nervonic Acid Predicts Mortality” J Ren Nutr. (2011) doi:10.1053/j.jrn.2011.05.005 
3. F. Babin et al. “Nervonic acid in red blood cell sphingomyelin in premature infants: An index of myelin maturation?” Lipids, vol. 28 pp. 627-630, 1993 
4. J. Chen et al. “Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan” The Journal of Nutritional Biochemistry, vol. 15 pp. 467-472, 2004 
5. N. Kasai et al. “Three-Dimensional Structural Model Analysis of the Binding Site of an Inhibitor, Nervonic Acid, of Both DNA Polymerase  and HIV-1 Reverse Transcriptase” J. Biochem, vol. 132 pp. 819-828, 2002

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