Methyl octadecatrienoate (all cis-6,9,12)Methyl octadecatrienoate (all cis-6,9,12)
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Methyl octadecatrienoate (all cis-6,9,12)

Methyl gamma-linolenate; C18:3 (all cis-6,9,12) Methyl ester

gamma-Linolenic acid (GLA) is found in high amounts in plant oils but can also be found in animals and other sources. GLA has become a popular nutritional supplement due to its many possible benefits. Dietary supplementation of GLA has been used to treat diseases that have low levels of PUFAs that result from a deficiency in the delta-6-desaturase enzyme since GLA already contains the n-6 desaturation.1 Some evidence has suggested that GLA can prevent the triggering of hypertension.2 GLA is elongated in vivo to dihomo-gamma-linolenic acid (C20:3) which can be converted by inflammatory cells to 15-(S)-hydroxy-8,11,13-eicosatrienoic acid and prostaglandin E1 both of which have anti-inflammatory and antiproliferative properties.3 GLA along with eicosapentaenoic acid have been found to enhance calcium absorption, reduce excretion and increase calcium deposition in bone, making it a possible osteoporosis treatment.4 Due to cancer cells having very low levels of cis-unsaturated fatty acids GLA, along with other cis-unsaturated fatty acids, are being investigated for their antitumor potential.
Cat# Size Price Qty Buy
1154 100 mg £84.38

Additional Information

Property Value or Rating
Product Size 100 mg
Manufacturer Matreya, LLC
Empirical Formula C19H32O2
CAS# 16326-32-2
Formula Weight 292
Solvent none
Source natural
Purity 99%
Analytical Methods GC, TLC
Natural Source plant
Solubility chloroform, hexane, ethyl ether
Physical Appearance liquid
Storage -20°C
Dry Ice No
Hazardous No
References

1. Y. Huang et al. “Cloning of delta 12- and delta 6-Desaturases from Mortierella alpina and Recombinant Production of gamma-Linolenic Acid in Saccharomyces cerevisiae” Lipids, Vol. 34(7) pp. 649-659, 1999 
2. D. Mills, M. Summers, R. Ward “Gamma Linolenic Acid Attenuates Cardiovascular Responses to Stress in Borderline Hypertensive Rats” Lipids, Vol. 20(9) pp. 573-577, 1985 
3. Y. Fan and R. Chapkin “Importance of Dietary gamma-Linolenic Acid in Human Health and Nutrition” The Journal of Nutrition, Vol. 128(9) pp. 1411- 1414, 1998 
4. M. Kruger et al. “Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis” Aging, Vol. 10(5) pp. 385-394, 1998

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