Methyl eicosatrienoate (all cis-5,8,11)/ml  1ml hexaneMethyl eicosatrienoate (all cis-5,8,11)/ml 1ml hexane
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Methyl eicosatrienoate (all cis-5,8,11)/ml 1ml hexane

C20:3 (all cis-5,8,11) Methyl ester; Mead acid methyl ester

Eicosatrienoic acid (all cis-5,8,11) is a product of oleic acid through D5 and D6 desaturation and elongation1 and it is one of the few polyunsaturated fatty acids produced de novo by animals. It is found mostly in cartilage, umbilical cords, fetuses, infants, and low vascular tissues. Eicosatrienoic acid (all cis-5,8,11) accumulates in essential fatty acid deficient animals and this is likely what accounts for where it is found. It has been found to suppresses osteoblast, but not osteoclast, activity in some studies. This may help in preventing calcification of fetal cartilage and lead to new therapeutic treatments.2 Eicosatrienoic acid (all cis-5,8,11) also has anti-inflammatory effects by inhibiting leukotrienes and is an inhibitor of platelet aggregation.3
Cat# Size Price Qty Buy
1179 1 mg/ml 1ml £264.38

Additional Information

Property Value or Rating
Product Size 1 mg/ml 1ml
Manufacturer Matreya, LLC
Empirical Formula C21H36O2
CAS# 14602-39-2
Formula Weight 320
Solvent hexane
Source natural
Purity 90%
Analytical Methods GC, TLC
Natural Source plant
Solubility chloroform, hexane, ethyl ether
Physical Appearance liquid
Storage -20°C
Dry Ice No
Hazardous Yes
References

1. H. Kawashima et al. “Production of 5,8,11-Eicosatrienoic Acid (Mead Acid) by a D6 Desaturation Activity-Enhanced Mutant Derived from a D12 Desaturase-Defective Mutant of an Arachidonic Acid-Producing Fungus, Mortierella alpina 1S-4” Applied and Environmental Microbiology, Vol. 63(5) pp. 1820-1825, 1997 
2. T. Hamazaki et al. “The Depressive Effects of 5,8,11-Eicosatrienoic Acid (20:3n-9) on Osteoblasts” Lipids, Vol. 44 pp. 97-102, 2009 
3. M. Lagarde et al. “Potentiating Effect of 5,8,11-Eicosatrienoic Acid on Human Platelet Aggregation” Lipids, Vol. 18(4) pp. 291-294, 1983

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