Methyl eicosatetraenoate (all cis-5,8,11,14)Methyl eicosatetraenoate (all cis-5,8,11,14)
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Methyl eicosatetraenoate (all cis-5,8,11,14)

Methyl arachidonate; C20:4 (all cis-5,8,11,14) Methyl ester

This high purity, polyunsaturated fatty acid is the methyl ester of arachidonic acid and is ideal as a standard. Arachidonic acid, an omega-6 fatty acid, is an essential fatty acid for most mammals and has many important biological functions in signaling, inflammation, nervous system functions and other processes. It is usually most abundant as a membrane lipid where it is esterified mainly at the sn2 position of phospholipids. It mediates numerous actions that range from induction of cell death to promotion of cell survival and enhancement of neurite extension. Some functions of arachidonic acid include modulation of the activities of protein kinases and ion channels, inhibition of neurotransmitter uptake, enhancement of synaptic transmission, and induction of cellular adhesion.1 Arachidonic acid has been suggested to be a critical mediator in amyloidbeta induced pathogenesis, leading to learning, memory, and behavioral impairments in Alzheimer's disease.2 In the CNS it plays a fast messenger role in synaptic modulation. An imbalance in n-6 fatty acid and n-3 fatty acid dietary intake has been suggested as the reason for several diseases, including inflammatory and autoimmune diseases, and has recently been blamed predominantly on arachidonic acid because it is a precursor for eicosanoids which have pro-inflammatory and immuno-regulatory activity.3 Arachidonic acid is also a precursor for autacoids and prostaglandins in mammals. It has been shown to trigger calcium signals in endothelial cells derived from human breast carcinoma but not from healthy cells. This has caused it to be considered a component of the tumor microenvironment although some results suggest that release of arachidonic acid from membrane lipids may help to prevent tumors.4
Cat# Size Price Qty Buy
1034 100 mg £117.19

Additional Information

Property Value or Rating
Product Size 100 mg
Manufacturer Matreya, LLC
Empirical Formula C21H34O2
CAS# 2566-89-4
Formula Weight 318
Solvent none
Source natural
Purity 99%
Analytical Methods GC, TLC
Natural Source fungal
Solubility chloroform, hexane, ethyl ether
Physical Appearance liquid
Storage -20°C
References

1. H. Katsuki and S. Okuda “Arachidonic acid as a neurotoxic and neurotrophic substance” Prog Neurobiol, vol. 46(6) pp. 607-636, 1995 
2. R. Sanchez-Mejia and L. Mucke “Phospholipase A2 and arachidonic acid in Alzheimer's disease” Biochim Biophys Acta, vol. 1801(8) pp. 784-790, 2010 
3. E. Bates “Eicosanoids, fatty acids and neutrophils: their relevance to the pathophysiology of disease” Prostaglandins Leukot Essent Fatty Acids, vol. 53 pp.75–86, 1995 
4. L. Levine “Proteasome inhibitors: Their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells” BMC Pharmacology, vol. 4(15), 2004

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