Methyl 9(Z),11(E)-Octadecadienoate

This product is a methyl ester and is ideal as a gas chromatography standard. 9(Z),11(E)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in lipids originating in ruminant animals including dairy products. It has several biological properties including anti-carcinogenic activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. 9(Z),11(E)-Octadecadienoic acid is the major natural isomer of CLA constituting 73% to 93% of the total CLA in dairy products2 and it appears to be the most biologically active isomer. It appears to enhance animal growth and inhibit osteoclast formation and activity from human cells,3 as well as decrease LDL:HDL and total:HDL cholesterol levels in humans.4