Methyl 2-fluoropalmitateMethyl 2-fluoropalmitate
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Methyl 2-fluoropalmitate

Methyl 2-fluoropalmitate
Activity: inactive ester of 2-fluoropalmitic acid

This product is the inactive methyl ester of the acyl-CoA synthase inhibitor 2-fluoropalmitic acid. 2-Fluoropalmitic acid is a synthetic inhibitor of palmitoyl-CoA formation by long chain acyl-CoA synthetase thereby inhibiting sphingosine biosynthesis and protein palmitoylation. This product is very useful in the investigation of sphingosine synthesis1, protein acylation2, and other biological mechanisms3. Other alpha-fluoro-fatty acids also inhibit their respective acyl-CoAs.4
Cat# Size Price Qty Buy
1718 10 mg £206.25

Additional Information

Property Value or Rating
Product Size 10 mg
Manufacturer Matreya, LLC
Activity inactive ester of 2-fluoropalmitic acid
Empirical Formula C17H33FO2
CAS# 137676-82-5
Formula Weight 288.4
Source synthetic
Purity 98+%
Analytical Methods TLC
Natural Source Synthetic
Melting Point 36-38°C
Solubility chloroform,ethanol,methanol
Physical Appearance A neat solid
Storage -20°C
References

1. R. Soltysiak et al. “D,L-alpha-Fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells” Biochim Biophys Acta, Vol. 792(2) pp. 214-226, 1984 
2. J. Zhang et al. “Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signaling” Journal of Biochemistry, Vol. 343, 541-549, 1999 
3. G. DeJesus and O. Bizzozero “Effect of 2-Fluoropalmitate, Cerulenin and Tunicamycin on the Palmitoylation and Intracellular Translocation of Myelin Proteolipid Protein” Neurochemical Research, Vol. 27(12) pp. 1669-1675, 2002 
4. M. Grillo et al. “Effect of alpha-Fluorination of Valproic Acid on Valproyl-S-Acyl-CoA Formation in Vivo in Rats” Drug Metabolism and Disposition, Vol. 29(9) pp. 1210-1215, 2001

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