lyso-Monosialoganglioside GM1lyso-Monosialoganglioside GM1
Move your mouse over image or click to enlarge

lyso-Monosialoganglioside GM1

lyso-GM1

Gangliosides1 are acidic glycosphingolipids containing sialic acids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF) by directly and tightly associating with Trk, the high-affinity tyrosine kinase-type receptor for NGF. It is the specific cell surface receptor for cholera toxin. Lyso gangliosides modulate cellular signaling and are being investigated for their immunological potential. They are ideal for obtaining synthetic neoganglioside proteins which can promote an efficient immune response against gangliosides and are therefore important biochemical tools.3 Lyso gangliosides also seem to have damage limiting effects on nerve cells. Lyso ganglioside GM1 is ideal for making well-defined GM1, anti-ganglioside GM1, and molecular probes.
Cat# Size Price Qty Buy
1518 500 ug £365.63

Additional Information

Property Value or Rating
Product Size 500 ug
Manufacturer Matreya, LLC
Empirical Formula C55H97N3O30 • NH3
CAS# 171483-40-2
Formula Weight 1297.4
Source semisynthetic
Purity 98+%
Analytical Methods TLC
Natural Source Animal/Bovine|Semi-synthetic
Solubility chloroform/methanol/DI water, 2:1:0.2
Physical Appearance A neat solid
Storage -20°C
References

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980 
2. T. Kolter, R. Proia, K. Sandhoff, “Combinatorial Ganglioside Biosynthesis” J. Biol. Chem., Vol. 277, No. 29, pp. 25859-25862, 2002 
3. O. Valiente et al. “Preparation of deacetyl-, lyso-, and deacetyl-lyso-GM3 by selective alkaline hydrolysis of GM3 ganglioside” Journal of Lipid Research, Vol. 42 pp. 1318-1324, 2001

Related Documents