GlobosidesGlobosides
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Globosides

Gb4; Globotetrahexosylceramide

Globoside is the most abundant neutral glycolipid in the erythrocyte membrane accumulating in lipid rafts of the cell wall. They are involved in cell communication, increase cell adhesion and function as receptors. It is an essential structure of the blood group P-antigen. A deficiency in this antigen leads to anti-globoside antibodies and the P blood group phenotypes. Globoside is a receptor for multiple toxins including P-fimbriated Escherichia coli, human parvovirus B191 and pierisin-1 toxin from the cabbage butterfly.2 In Tay-Sachs and Sandhoff disease globoside can accumulate due to the deficiency of the beta-hexosaminidase.3
Cat# Size Price Qty Buy
1068 5 mg £445.31

Additional Information

Property Value or Rating
Product Size 5 mg
Manufacturer Matreya, LLC
Empirical Formula C68H126N2O23
CAS# 11034-93-8
Formula Weight 1340 (tetracosanoyl)
Solvent none
Source natural
Purity 98+%
Analytical Methods TLC; identity confirmed by MS
Natural Source porcine RBC
Solubility chloroform/methanol, 2:1; DMSO, hot methanol
Physical Appearance solid
Storage -20°C
Dry Ice No
Hazardous No
References

1. Boel Lanne et al, The Journal of Biological Chemistry, Vol. 270 pp. 9017, 1995 
2. Yuko Matsushima-Hibiya, The Journal of Biological Chemistry, Vol. 278 pp. 9972, 2003 
3. R. A. Gravel, M. M. Kaback, R. Proia, K. Sandhoff, K. Suzuki, and K. Suzuki. in The Metabolic and Molecular Bases of Inherited Disease (C. R. Scriver, W. S. Sly, B. Childs, A. L. Beaudet, D. Valle, K. W. Kinzler, and B. Vogelstein, eds) pp. 3827–3876, McGraw-Hill Inc., New York, 2001

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