Fucosylated monosialoganglioside GM1, (porcine thyroid)Fucosylated monosialoganglioside GM1, (porcine thyroid)
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Fucosylated monosialoganglioside GM1, (porcine thyroid)

Fucosyl-GM1

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. Fucosyl-GM1 is a tumor associated ganglioside and is an antigen expressed in small cell lung cancer that is being investigated as a target for vaccines against cancer cells.3 It has been found that Fucosyl-GM1 demonstrates some of the same binding properties as the similar GM1 ganglioside such as affinity for cholera toxin B subunit and interaction with amyloid-beta protein.4
Cat# Size Price Qty Buy
1526 500 ug £557.81

Additional Information

Property Value or Rating
Product Size 500 ug
Manufacturer Matreya, LLC
Empirical Formula C79H141N3O35 • NH3
CAS# 71812-11-8
Formula Weight 1710
Source natural
Purity 98+%
Analytical Methods TLC; identity confirmed by MS
Natural Source Animal/Porcine
Solubility chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
Physical Appearance A neat solid
Storage -20°C
References

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980 
2. T. Kolter, R. Proia, K. Sandhoff, Combinatorial Ganglioside Biosynthesis. J. Biol. Chem., July Vol. 277, No. 29, pp. 25859-25862, 2002 
3. G. Ragupathi et al. “Immunization of mice with fucosyl-GM1 conjugated with keyhole limpet hemocyanin results in antibodies against human small-cell lung cancer cells” Cancer Immunology, Immunotherapy, Vol. 48 pp. 483-492, 1999 
4. M. Yanagisawa, T. Ariga, R. Yu “Fucosyl-GM1 expression and amyloid-ß protein accumulation in PC12 cells” Journal of Neuroscience Research, Vol. 84 pp. 1343-1349, 2006

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