Disialoganglioside GD1b, (NH4+ salt)Disialoganglioside GD1b, (NH4+ salt)
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Disialoganglioside GD1b, (NH4+ salt)

GD1b

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.2 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. High levels of GD1b are found in the gliomas and astrocytomas. It can inhibit the efflux of K+ through K+ channels which results in the suppression of apoptosis.3 GD1b acts as a bacterial toxin receptor for tetanus and botulinus as well as for the BK virus.4
Cat# Size Price Qty Buy
1501 1 mg £267.19

Additional Information

Property Value or Rating
Product Size 1 mg
Manufacturer Matreya, LLC
Empirical Formula C84H148N4O39 • 2NH3 (stearoyl)
CAS# 19553-76-5
Formula Weight 1872.2
Source natural
Purity 98+%
Analytical Methods TLC, identity confirmed by MS
Natural Source Animal/Bovine
Solubility chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
Physical Appearance A neat solid
Storage -20°C
References

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980 
2. S. Birkle, G. Zeng, L. Gao, R.Yu, and J. Aubry, Biochimie, 85, 455–463, 2003 
3. X. Chen et al., Journal of Lipid Research, Vol. 46 pp. 2580-2585, 2005 
4. K. Turton, J. Chaddock and K. Acharya, Trends in Biochemical Sciences, Vol. 27:11 pp. 552-558, 2002

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