D-threo-PDMPD-threo-PDMP
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D-threo-PDMP

D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol•HCl; Activity: glucosylceramide synthase inhibitor

This product is a glucosylceramide synthase inhibitor, an enzyme that is essential for the synthesis of a very large number of different glycolipids that are found in many organisms.1 PDMP has four possible isomers due to its two chiral centers (D-threo, L-threo, D-erythro, and L-erythro). The D-threo isomer has been shown to be the active glucosylceramide synthase inhibitor.2 Due to PDMP’s ability to inhibit the joining of ceramides with carbohydrates there can be an accumulation of ceramide in the cells and this can lead to apoptosis. This process has been suggested as a treatment for cancer.3 In addition to its stereochemistry, the acyl chain of PDMP has a very marked effect on the intensity of the inhibitory action of the molecule.
Cat# Size Price Qty Buy
1756 10 mg £323.44

Additional Information

Property Value or Rating
Product Size 10 mg
Manufacturer Matreya, LLC
Activity glucosylceramide synthase inhibitor
Empirical Formula C23H38N2O3 • HCl
CAS# 109836-82-0
Formula Weight 427
Source synthetic
Purity 98+%
Analytical Methods TLC
Natural Source Synthetic
Solubility ethanol, methanol
Physical Appearance A neat solid
Storage -20°C
References

1. R. Vunnam, N. Radin, “Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain” Chem Phys Lipids, Vol. 26(3) pp. 265-278, 1980 
2. N. Radin et al. “Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells” Journal of Cellular Physiology, Vol. 141(3) pp. 573-583, 1989 
3. N. Radin, et al., “Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth” Journal of Lipid Research, Vol. 36 pp. 611-621, 1995

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