D,L-erythro-PDMPD,L-erythro-PDMP
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D,L-erythro-PDMP

D,L-erythro-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol•HCl

This product inhibits the growth of cells, including cancer cells. D-threo-PDMP has been shown to inhibit cell growth by inhibiting the enzyme glucosylceramide synthase1 but erythro-PDMP inhibits growth according to a different mechanism. PDMP has four possible isomers (D-threo, L-threo, D-erythro, and L-erythro) due to its two chiral centers. This product (D,L-erythro-PDMP) is a mixture of D-erythro (1R,2R) and L-erythro (1S,2S). The D-threo isomer has been shown to be the active glucosyl ceramide synthetase inhibitor.2 Although erythro-PDMP does not inhibit glucosylceramide synthase it does cause cell growth inhibition similar to threo-PDMP.3 This has been suggested as a treatment for cancer.4 In addition to its stereochemistry, the acyl chain of PDMP has a very marked effect on the intensity of the inhibitory action of the molecule.
Cat# Size Price Qty Buy
1755 100 mg £220.31

Additional Information

Property Value or Rating
Product Size 100 mg
Manufacturer Matreya, LLC
Empirical Formula C23H38N2O3 • HCl
CAS# 109760-77-2
Formula Weight 427
Source synthetic
Purity 98+%
Analytical Methods TLC
Natural Source Synthetic
Solubility ethanol, methanol, chloroform, DMSO
Physical Appearance A neat solid
Storage -20°C
References

1. R. Vunnam, N. Radin “Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain” Chem Phys Lipids, Vol. 26(3) pp. 265-278, 1980 
2. N. Radin et al. “Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells” Journal of Cellular Physiology, Vol. 141(3) pp. 573–583, 1989 
3. N. Radin et al. “Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts” Journal of Biochemsitry, vol. 108:4 pp. 525-530, 1990 
4. N. Radin, et al. “Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth” Journal of Lipid Research, Vol. 36 pp. 611-621, 1995

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