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Sphingosine, C18 chain

Sphingosine is a characteristic structural unit of many sphingolipids such as ceramides, gangliosides, globosides, sulfatides, sphingomyelin, and others.1,2 It is most abundant in nervous tissue and cell membranes. Sphingosine with an 18-carbon chain and a double bond at carbon 4 is the most abundant sphingosine in animal tissues. Lysosphingolipids inhibit protein kinase C activity resulting in the pathogenesis of sphingolipidoses such as Krabbe's disease and Gaucher's disease.3 Sphingosine can be phosphorylated via two kinases to form sphingosine-1-phosphate, which has important signaling functions. While sphingosines and ceramides can induce apoptosis,4 sphingosine-1-phosphate can promote cell survival or proliferation. Sphingosine has been shown to cause an increase in the cytoplasmic calcium level of cells.
Cat# Size Price Qty Buy
1802 25 mg £67.15

Additional Information

Property Value or Rating
Product Size 25 mg
Manufacturer Matreya, LLC
Empirical Formula C18H37NO2
CAS# 123-78-4
Formula Weight 299.5
Solvent none
Source synthetic
Purity 98+%
Analytical Methods TLC, GC
Natural Source Synthetic
Solubility chloroform, ethanol, methanol, DMSO
Physical Appearance A neat solid
Storage -20°C

1. A. Merrill, Jr., The Journal of Biological Chemistry, Vol. 277(29) pp. 25843–25846, 2002 
2. J. Shayman, Kidney International, Vol. 58 pp. 11-26, 2000 
3. Y. Hannun and R. Bell, Vol. 235:4789 pp. 670, 1987 
4. V. Nava et al., Cancer Research, Vol. 60 pp. 4468-4474, 2000

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