Ceramide trihexosides, (top spot)Ceramide trihexosides, (top spot)
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Ceramide trihexosides, (top spot)

CTH with non-hydroxy fatty acid side chain

Ceramide trihexoside is a glycosphingolipid found mostly in mammalian cell membranes. It is involved in cellular signaling and has been identified as a receptor for various toxins including shiga toxins and shiga-like toxins.1 Some toxins, such as veratoxins from Escherichia coli, require specific fatty acids on the ceramide portion of CTH to show affinity in binding. An accumulation of CTH in the cellular membranes due to a lack of alpha-galactosidase to convert it into lactosyl ceramide results in Fabry disease.2 This product can be used as an excellent standard for the identification of CTH in Fabry disease by HPLC3 and mass spectrometry.4 An inability to convert CTH to globoside due to mutations in the gene sequence leads to the Pk Blood Group Phenotype. It appears that under certain conditions CTH can enhance anticoagulant activity. CTH has also been studied as a tool to investigate lymphocyte activation.5
Cat# Size Price Qty Buy
1513 0.5 mg £300.00

Additional Information

Property Value or Rating
Product Size 0.5 mg
Manufacturer Matreya, LLC
Empirical Formula C54H101NO18 (stearoyl)
Formula Weight 1052.4
Solvent none
Source natural
Purity 98+%
Analytical Methods TLC, identity confirmed by MS
Natural Source Animal/Porcine RBC
Solubility chlorofom/methanol, 2:1
Physical Appearance A neat solid
Storage -20°C
References

1. S. Ashkenazi and T. G. Cleary, J Clin Microbiol, Vol. 27:6 pp. 1145-1150, 1989 
2. S. Bekri et al., Cardiovasc Hematol Agents Med Chem, Vol. 4:4 pp. 289–297, 2006 
3. J. Groener et al., Clin Chem., Vol. 53:4 pp.742-747, 2007 
4. K. Mills, A. Johnson, B. Winchester, FEBS Lett., Vol. 515 pp. 171-176, 2002 
5. C. Menge et al., Vet Immunol Immunopathol., Vol. 83 pp.19-36, 2001

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