2-Hydroxyeicosanoic acid2-Hydroxyeicosanoic acid
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2-Hydroxyeicosanoic acid

2-Hydroxy C20:0 fatty acid

2-Hydroxy very long chain fatty acids are abundant in nervous tissues and are components of cerebrosides and sulfatides, which are mostly found in the myelin of nervous tissues. 2-Hydroxyeicosanoic acid has been reported in the marine sponge Verongula gigantean.1 2-Hydroxy fatty acids are common in cosmetics and skin creams and lotions. They are formed by the oxidation of saturated fatty acids by the enzyme fatty acid 2-hydroxylase. This enzyme is also responsible for the formation of 2-hydroxy galactolipids in the peripheral nervous system.2 alpha-Oxidation of 2-hydroxy fatty acids to CO2 and fatty acid occurs in the peroxisome and is unique from the alpha-oxidation of beta-carbon branched fatty acids such as phytanic acid. Cells from Zellweger syndrome and peroxisome-deficient cells are unable to undergo alpha-oxidation although patients with other peroxisomal disorders such as X-linked adrenoleukodystrophy, Refsum disease, and rhizomelic chondrodysplasia punctata are able.3 2-Hydroxy fatty acids are undergoing much research and various methods of analysis are being investigated.4
Cat# Size Price Qty Buy
1709 25 mg £145.31

Additional Information

Property Value or Rating
Product Size 25 mg
Manufacturer Matreya, LLC
Empirical Formula C20H40O3
CAS# 16742-48-6
Formula Weight 328.5
Solvent none
Source synthetic
Purity 98+%
Analytical Methods TLC, GC
Natural Source Synthetic
Melting Point 91-92°C
Solubility chloroform/methanol,5:1
Physical Appearance A neat solid
Storage -20°C
References

1. N Carballiera et al. “2-Hydroxy fatty acids from marine sponges 2. The phospholipid fatty acids of the caribbean spongesVerongula gigantea andAplysina archeri” Lipids, vol. 24 pp. 229-232, 1989 
2. E. Maldonado et al. “FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin” Journal of Lipid Research, Vol. 49 pp. 153-161, 2008 
3. R. Sandhir, M. Khan, and I. Singh “Identification of the Pathway of alpha-Oxidation of Cerebronic Acid in Peroxisomes” Lipids, Vol. 35(10) pp. 1127- 1133, 2000 
4. N. Alderson, M.Walla, and H. Hama “A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gas chromatography-mass spectrometry” Journal of Lipid Research, Vol. 46 pp. 1569-1579, 2005

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