10(E),12(Z)-Octadecadienoic acid10(E),12(Z)-Octadecadienoic acid
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10(E),12(Z)-Octadecadienoic acid

10 trans, 12 cis-CLA

10(E),12(Z)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in lipids originating in ruminant animals, including dairy products. It has several biological properties including anticarcinogenic activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. Animals fed a diet containing high levels of CLA have been observed to have improved feed efficiency (lean body mass increased while body fat decreased) and this seems to be due, mainly or exclusively, to the 10(E),12(Z)-Octadecadienoic acid.2 However, this isomer appears to increase oxidative stress and inflammatory biomarkers in obese men, which can lead to insulin resistance.3,4 10(E),12(Z)-Octadecadienoic acid increases LDL:HDL cholesterol and total:HDL cholesterol in humans.
Cat# Size Price Qty Buy
1249 25 mg £145.31

Additional Information

Property Value or Rating
Product Size 25 mg
Manufacturer Matreya, LLC
Empirical Formula C18H32O2
CAS# 2420-44-2
Formula Weight 280
Solvent none
Source synthetic
Purity 98+%
Analytical Methods GC, TLC, identity confirmed by MS
Solubility ethanol,methanol,hexane,chlorofom
Physical Appearance liquid
Storage -20°C
Dry Ice No
Hazardous No
References

1. Helen B. MacDonald, Journal of the American College of Nutrition, Vol. 19, No. 90002, 111S-118S, 2000
2. Yanwen Wang and Peter J. H. Jones, The American Journal of Clinical Nutrition, June, Vol. 79, No. 6, 1153S-1158S, 2004 
3. Ulf Risérus, MMed, Samar Basu, PhD; Stefan Jovinge, MD, PhD; Gunilla Nordin Fredrikson, PhD; Johan Ärnlöv, MD; Bengt Vessby, MD, PhD, Circulation, 106:1925, 2002 
4. Soonkyu Chung, J. Mark Brown, J. Nathan Provo, Robin Hopkins and Michael K. McIntosh, The Journal of Biological Chemistry, September, Vol. 280: 38445, 2005

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