1,2-Distearoyl-sn-glycero-3-phosphatidic acid, (Na+ salt)1,2-Distearoyl-sn-glycero-3-phosphatidic acid, (Na+ salt)
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1,2-Distearoyl-sn-glycero-3-phosphatidic acid, (Na+ salt)

DSPA

This phosphatidic acid is a well-defined phospholipid acylated with C18:0 fatty acids at the sn-1 and sn-2 positions. A model of an anionic phospholipid layer using 1,2-distearoyl-sn-glycero-3-phosphatidic acid has been shown to be very compact and to prevent permeation by tetraethylammonium cations.1 Phosphatidic acid (PA) is an important acidic lipid that is only found in relatively small amounts in comparison to other lipids. Phosphatidic acid acts as the precursor to a number of phospholipids and triacylglycerols, is integral in forming the shape of cellular membranes,2 has roles in cellular signaling,3 and has a role in vesicle fission and fusion. PA is generally synthesized by the acylation of glycerophosphate but can also be synthesized by the phosphorylation of 1,2-diacyl-sn-glycerol or the hydrolysis of phosphatidylcholine. PA can be converted to diacylglycerols which are important cellular signaling agents.4
Cat# Size Price Qty Buy
1430 100 mg £84.38

Additional Information

Property Value or Rating
Product Size 100 mg
Manufacturer Matreya, LLC
Empirical Formula C39H76O8P • Na
CAS# 108321-18-2
Formula Weight 727
Solvent none
Source synthetic
Purity 98+%
Analytical Methods TLC
Natural Source Synthetic
Solubility chloroform/methanol/acetic acid, 4:1:0.1
Physical Appearance A neat solid
Storage -20°C
References

1. L. Monzon and L. Yudi “Cation adsorption at a distearoylphosphatidic acid layer adsorbed at a liquid/liquid interface” Electrochemica Acta, Vol. 52(24) pp.6873-6879, 2007 
2. E. Kooijman et al. “Modulation of Membrane Curvature by Phosphatidic Acid and Lysophosphatidic Acid” Traffic, Vol. 4(3) pp. 162-174, 2003 
3. K. Athenstaedt and G. Daum “Phosphatidic acid, a key intermediate in lipid metabolism” European Journal of Biochemistry, Vol. 266 pp. 1-16, 1999 
4. M. Hodgkin et al. “Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?” Trends in Biochemical Sciences, Vol. 23(6) pp. 200-204, 1998

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