1,2-Dipalmitoyl-sn-glycero-3-phosphatidic acid (Na+ salt)1,2-Dipalmitoyl-sn-glycero-3-phosphatidic acid (Na+ salt)
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1,2-Dipalmitoyl-sn-glycero-3-phosphatidic acid (Na+ salt)

DPPA

This phosphatidic acid is a well-defined phospholipid acylated with C16:0 fatty acids at the sn-1 and sn-2 positions. Phosphatidic acid is an important acidic lipid that is only found in relatively small amounts in comparison to other lipids. It acts as the precursor to a number of phospholipids and triacylglycerols, is integral in forming the shape of cellular membranes,1 has functions in cellular signaling,2 and has a role in vesicle fission and fusion. Phosphatidic acid is generally synthesized by the acylation of glycerophosphate but can also be synthesized by the phosphorylation of 1,2-diacyl-snglycerol or the hydrolysis of phosphatidylcholine. Phosphatidic acid can be converted to diacylglycerols which are important cellular signaling agents.3 The metabolism of phosphatidic acid has been shown to change due to external stimuli in the pathogen Trypanosoma cruzi and this could be used to develop a treatment for diseases caused by this microorganism.4 Dipalmitoyl phosphatidic acid has been found to be useful in the formation of lipid vesicles which are used to carry drugs to targeted cells.5
Cat# Size Price Qty Buy
1429 100 mg £84.38

Additional Information

Property Value or Rating
Product Size 100 mg
Manufacturer Matreya, LLC
Empirical Formula C35H68O8P • Na
CAS# 71065-87-7
Formula Weight 670.9
Solvent none
Source synthetic
Purity 98+%
Analytical Methods TLC
Natural Source Synthetic
Solubility chloroform/methanol/acetic acid, 4:1:0.1
Physical Appearance A neat solid
Storage -20°C
References

1. E. Kooijman et al. “Modulation of Membrane Curvature by Phosphatidic Acid and Lysophosphatidic Acid” Traffic, Vol. 4(3) pp. 162-174, 2003 
2. K. Athenstaedt and G. Daum “Phosphatidic acid, a key intermediate in lipid metabolism” European Journal of Biochemistry, Vol. 266 pp. 1-16, 1999 
3. M. Hodgkin et al. “Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?” Trends in Biochemical Sciences, Vol. 23(6) pp. 200-204, 1998 
4. A. Gimenez et al. “Regulation of Phosphatidic Acid Levels in Trypanosoma cruzi” Lipids, vol. 46 pp. 969-979, 2011 
5. L. Panicker “Effect of propyl paraben on the dipalmitoyl phosphatidic acid vesicles” Journal of Colloid and Interface Science, vol. 311 pp. 407-416, 2007

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